Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat
publication in Cell, 154(3), 691-703 (2013)
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
publication in Nature Genetics, 21(16), 3546-57 (2013)
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
publication in Nature Medicine,18, 766-773 (2012)
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
publication in Natue, 478(7367), 114-118 (2011)
Science Magazine Breakthrough of the Year: Knockout rats are runner up!
Science Vol. 330. No 6011, p. 1605, NEWS FOCUSKnockout rats are among the runners up of Science Magazine's Breakthrough of the Year selection. This acknowledges the recent development in zink finger nuclease, knockout and transposon technologies which could mean that "knockout and genetically modified rats may soon displace their smaller cousins in lab cages around the world".
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
publication in Nature, 467(7314), 460-464 (2010)
Science Magazine News: One-Two Punch Elevates Rats to the Knockout Ranks
Science Vol. 329. No 5994, p. 892 NEWS OF THE WEEKScience Magazine NEWS OF THE WEEK on the latest developments in knockout rat technologies. Dennis Normile interviewed Tim Aitman (Imperial College London) and refers to Aron Geurths' work with Zink Finger Nuclease technolgy (Medical College of Wisconsin, Milwaukee) and Zsuzsanna Izsvaks' work with transposons (Max Delbrück Center for Molecular Medicine, Berlin), all of them Principal Investigators in the EURATRANS consortium.
