EURATRANS

European large-scale functional genomics in the rat for translational research

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  1. Aizawa-Abe M, Ebihara K, Ebihara C, Mashimo T, Takizawa A, Tomita T, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K. (2013): Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Physiol Genomics, 45(17), 786-93.
    PubMed Open Access

  2. Alam I, Koller DL, Sun Q, Roeder RK, Cañete T, Blázquez G, López-Aumatell R, Martínez-Membrives E, Vicens-Costa E, Mont C, Díaz S, Tobeña A, Fernández-Teruel A, Whitley A, Strid P, Diez M, Johannesson M, Flint J, Econs MJ, Turner CH, Foroud T (2011): Heterogeneous stock rat: A unique animal model for mapping genes influencing bone fragility. Bone, 48(5), 1169-1177.
    PubMed Open Access

  3. Arends D, van der Velde KJ, Prins P, Broman KW, Möller S, Jansen RC, Swertz MA. (2012): xQTL workbench: a scalable web environment for multi-level QTL analysis. Bioinformatics, 28(7),1042-4.
    PubMed Open Access

  4. Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MC, Keane TM, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett MR, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams DJ, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, Aitman TJ. (2013): Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell, 154(3), 691-703.
    PubMed Open Access

  5. Bäckdahl L, Ekman D, Jagodic M, Olsson T, Holmdahl R. (2014): Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research. BMC Genomics, 15, 391.
    PubMed Open Access

  6. Bailey EL, McBride MW, Crawford W, McClure JD, Graham D, Dominiczak AF, Sudlow CL, Smith C, Wardlaw JM. (2014): Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathol Appl Neurobiol., 40(7), 855-72.
    PubMed Open Access

  7. Baud A, Calderari S, Mott R, Flint J, Gauguier D; Rat Genome Sequencing and Mapping Consortium. (2013): Genome sequencing and genetic mapping to dissect the genetic basis of complex traits. Med Sci (Paris), 29(6-7), 671-4.
    PubMed Open Access

  8. Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J. (2013): Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), 767-75.
    PubMed Open Access

  9. Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T. (2012): A rat model for LGI1-related epilepsies. Hum Mol Genet, 21(16), 3546-57.
    PubMed Open Access

  10. Blair K, Leitch HG, Mansfield W, Dumeau CE, Humphreys P, Smith AG (2012): Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells. Biology Open, 1, 58-65.
    PubMed Open Access

  11. Bottolo L, Chadeau-Hyam M, Hastie DI, Langley SR, Petretto E, Tiret L, Tregouet D, Richardson S (2011): ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration. Bioinformatics, 27(4), 587-8.
    PubMed Open Access

  12. Bottolo L, Chadeau-Hyam M, Hastie DI, Zeller T, Liquet B, Newcombe P, Yengo L, Wild PS, Schillert A, Ziegler A, Nielsen SF, Butterworth AS, Ho WK, Castagné R, Munzel T, Tregouet D, Falchi M, Cambien F, Nordestgaard BG, Fumeron F, Tybjærg-Hansen A, Froguel P, Danesh J, Petretto E, Blankenberg S, Tiret L, Richardson S. (2013): GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. PLoS Genet., 9(8), e1003657.
    PubMed Open Access

  13. Cazier JB, Kaisaki PJ, Argoud K, Blaise B, Veselkov K, Ebbels T, Tsang T, Wang Y, Bihoreau MT, Mitchell SC, Holmes E, Lindon JC, Scott J, Nicholson JK, Dumas ME, Gauguier D (2012): Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase. J Proteome Res, 11(2), 631-42.
    PubMed

  14. Chen Y, Blair K, Smith A. (year): Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports., 1(3), 209-17.
    PubMed Open Access

  15. Chuykin I, Schulz H, Guan K, Bader M (2013): Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/β-catenin signaling promotes differentiation into visceral endoderm. J Cell Sci, 126, 128-38
    PubMed Open Access

  16. Colaianna M, Schiavone S, Zotti M, Tucci P, Morgese MG, Bäckdahl L, Holmdahl R, Krause KH, Cuomo V, Trabace L (2013): Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. Antioxid Redox Signal, 18(20), 1385-95.
    PubMed Open Access

  17. Colomé-Tatché M, Cortijo S, Wardenaar R, Morgado L, Lahouze B, Sarazin A, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, Colot V, Johannes F. (2012): Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc Natl Acad Sci U S A, 109(40), 16240-5.
    PubMed Open Access

  18. Cunningham F, Amode MR, Barrell D, Beal K, Billis K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fitzgerald S, Gil L, Girón CG, Gordon L, Hourlier T, Hunt SE, Janacek SH, Johnson N, Juettemann T, Kähäri AK, Keenan S, Martin FJ, Maurel T, McLaren W, Murphy DN, Nag R, Overduin B, Parker A, Patricio M, Perry E, Pignatelli M, Riat HS, Sheppard D, Taylor K, Thormann A, Vullo A, Wilder SP, Zadissa A, Aken BL, Birney E, Harrow J, Kinsella R, Muffato M, Ruffier M, Searle SM, Spudich G, Trevanion SJ, Yates A, Zerbino DR, Flicek P. (2015): Ensembl 2015. Nucleic Acids Res., 43(Database issue), D662-9.
    PubMed Open Access

  19. Dumas ME, Gauguier D (2012): mQTL – The missing link between metabolome-wide association studies and systems biology. Genetics meets Metabolomics: from Experiment to Systems Biology. K Suhre Ed. Springer, New York, NY, USA, pp 233-254.
    go to: Springer website

  20. Dumas ME, Kinross J, Nicholson JK (2014): Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology, 146(1), 46-62.
    PubMed Open Access

  21. Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai V, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K. (2015): Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis. Hum Mol Genet., [Epub ahead of print]
    PubMed

  22. Falak S, Schafer S, Baud A, Hummel O, Schulz H, Gauguier D, Hubner N, Osborne-Pellegrin M. (2014): title.Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat.Physiol Genomics, 46(12), 418-28.
    PubMed Open Access

  23. Flicek P, Amode MR, Barrell D, Beal K, Billis K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fitzgerald S, Gil L, Girón CG, Gordon L, Hourlier T, Hunt S, Johnson N, Juettemann T, Kähäri AK, Keenan S, Kulesha E, Martin FJ, Maurel T, McLaren WM, Murphy DN, Nag R, Overduin B, Pignatelli M, Pritchard B, Pritchard E, Riat HS, Ruffier M, Sheppard D, Taylor K, Thormann A, Trevanion SJ, Vullo A, Wilder SP, Wilson M, Zadissa A, Aken BL, Birney E, Cunningham F, Harrow J, Herrero J, Hubbard TJ, Kinsella R, Muffato M, Parker A, Spudich G, Yates A, Zerbino DR, Searle SM. (2013): Ensembl 2014. Nucl Acids Res, 42(Database issue), D749-55.
    PubMed Open Access

  24. Flytzani S, Stridh P, Guerreiro-Cacais AO, Marta M, Hedreul MT, Jagodic M, Olsson T (2013): Anti-MOG antibodies are under polygenic regulation with the most significant control coming from the C-type lectin-like gene locus. Genes Immun., 14(7), 409-19.
    PubMed

  25. Fumoto N, Mashimo T, Masui A, Ishida S, Mizuguchi Y, Minamimoto S, Ikeda A, Takahashi R, Serikawa T, Ohno Y. (2014): Evaluation of seizure foci and genes in the Lgi1(L385R/+) mutant rat. Neurosci Res, 80:69-75.
    PubMed

  26. Graham LA, Padmanabhan S, Fraser NJ, Kumar S, Bates JM, Raffi HS, Welsh P, Beattie W, Hao S, Leh S, Hultstrom M, Ferreri NR, Dominiczak AF, Graham D, McBride MW. (2014): Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), 551-8.
    PubMed Open Access

  27. Guo* W, Schafer* S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, Macrae CA, Spallek B, Fischer R, Perrot A, Ozcelik C, Saar K, Hubner N, Gotthardt M. (2012): RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nature Medicine, 18, 766-773.
    * contributed equally to this work
    PubMed Open Access

  28. Hedjazi L, Gauguier D, Zalloua PA1, Nicholson JK, Dumas ME, Cazier JB. (2015): mQTL.NMR: An Integrated Suite for Genetic Mapping of Quantitative Variations of (1)H NMR-Based Metabolic Profiles. Anal Chem, 87(8), 4377-84.
    PubMed

  29. Heinig M, Colomé-Tatché M, Taudt A, Rintisch C, Schafer S, Pravenec M, Hubner N, Vingron M, Johannes F. (2015): histoneHMM: Differential analysis of histone modifications with broad genomic footprints. BMC Bioinformatics, 16(1), 60.
    PubMed Open Access

  30. Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG; Cardiogenics Consortium, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA. (2010): A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature, 467(7314), 460-464.
    PubMed Open Access

  31. Hermsen R, de Ligt J, Spee W, Blokzijl F, Schäfer S, Adami E, Boymans S, Flink S, van Boxtel R, van der Weide RH, Aitman T, Hübner N, Simonis M, Tabakoff B, Guryev V, Cuppen E. (2015): Genomic landscape of rat strain and substrain variation. BMC Genomics, 16, 357.
    PubMed Open Access

  32. Holmdahl R (2010): At last; Rats lacking B cells. Eur J Immunol, 40(10), 2680-1.
    PubMed Open Access

  33. Houstek J, Hejzlarova K, Vrbacky M, Drahota Z, Landa V, Zidek V, Mlejnek P, Simakova M, Silhavy J, Miksik I, Kazdova L, Oliyarnyk O, Kurtz TW, Pravenec M (2012): Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains. Physiological Genomics, 44(9), 487-94.
    PubMed Open Access

  34. Hultqvist M, Sareila O, Vilhardt F, Norin U, Olsson LM, Olofsson P, Hellman U, Holmdahl R (2011): Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats. Redox Signal, 14(12), 2373-83.
    PubMed

  35. Johnson MD, Mueller M, Adamowicz-Brice M, Collins MJ, Gellert P, Maratou K, Srivastava PK, Rotival M, Butt S, Game L, Atanur SS, Silver N, Norsworthy PJ, Langley SR, Petretto E, Pravenec M, Aitman TJ. (2104): Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease. PLoS Genet., 10(12), e1004813.
    PubMed Open Access

  36. Kaisaki PJ, Otto GW, McGouran JF, Toubal A, Argoud K, Waller-Evans H, Finlay C, Caldérari S, Bihoreau MT, Kessler BM, Gauguier D, Mott R. (2014): Genetic control of differential acetylation in diabetic rats. PLoS One, 9(4), e94555.
    PubMed Open Access

  37. Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J. (2014): Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell Rep., 8(4), 1210-24.
    PubMed Open Access

  38. Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z. (2013): Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J., 27(3), 930-41.
    PubMed Open Access

  39. Laaksonen H, Guerreiro-Cacais AO, Adzemovic MZ, Parsa R, Zeitelhofer M, Jagodic M, Olsson T. (2014): The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation. Genes Immun., 15(7), 457-65.
    PubMed

  40. Langley SR, Bottolo L, Kunes J, Zicha J, Zidek V, Hubner N, Cook SA, Pravenec M, Aitman TJ, Petretto E. (2013): Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc. research, 97(4), 653-65.
    PubMed Open Access

  41. Leitch HG, Blair K, Mansfield W, Ayetey H, Humphreys P, Nichols J, Surani MA, Smith A (2010): Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development and stem cells, 137(14), 2279-87.
    PubMed Open Access

  42. Liška F, Mancini M, Krupková M, Chylíková B, Křenová D, Šeda O, Šilhavý J, Mlejnek P, Landa V, Zídek V, d' Amati G, Pravenec M, Křen V (2014): Plzf as a candidate gene predisposing the spontaneously hypertensive rat to hypertension, left ventricular hypertrophy, and interstitial fibrosis. Am J Hypertens, 27(1), 99-106.
    PubMed

  43. Liskovykh M, Chuykin I, Ranjan A, Safina D, Popova E, Tolkunova E, Mosienko V, Minina J, Zhdanova N, Mullins JJ, Bader M, Alenina N, Tomilin A (2011): Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats (2011): PLoS One, 6, e273.
    PubMed Open Access

  44. Lopez LM, Hill WD, Harris SE, Valdes Hernandez M, Munoz Maniega S, Bastin ME, Bailey E, Smith C, McBride M, McClure J, Graham D, Dominiczak A, Yang Q, Fornage M, Ikram MA, Debette S, Launer L, Bis JC, Schmidt R, Seshadri S, Porteous DJ, Starr J, Deary IJ, Wardlaw JM. (2015): Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), 341-7.
    PubMed Open Access

  45. Low TY, van Heesch S, van den Toorn H, Giansanti P, Cristobal A, Toonen P, Schafer S, Hübner N, van Breukelen B, Mohammed S, Cuppen E, Heck AJ, Guryev V. (2013): Quantitative and Qualitative Proteome Characteristics Extracted from In-Depth Integrated Genomics and Proteomics Analysis. Cell Rep. 5(5), 1469-78.
    PubMed Open Access

  46. Maatz H, Jens M, Liss M, Schafer S, Heinig M, Kirchner M, Adami E, Rintisch C, Dauksaite V, Radke MH, Selbach M, Barton PJ, Cook SA, Rajewsky N, Gotthardt M, Landthaler M, Hubner N (2014): RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. J Clin Invest, 124(8), 3419-30.
    PubMed Open Access

  47. McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA (2011): Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature, 478(7367), 114-118.
    PubMed Open Access

  48. McLachlan J, Beattie E, Murphy MP, Koh-Tan CH, Olson E, Beattie W, Dominiczak AF, Nicklin SA, Graham D. (2014): Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. J Hypertens, 32(3), 555-64.
    PubMed Open Access

  49. Meek S, Sutherland L, Burdon T. (2015): Tuning differentiation signals for efficient propagation and in vitro validation of rat embryonic stem cell cultures. Methods Mol Biol., 1212, 73-85.
    PubMed

  50. Meek S, Wei J, Sutherland L, Nilges B, Buehr M, Tomlinson SR, Thomson AJ, Burdon T. (2013): Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells. Stem Cells, 31(10), 2104-15.
    PubMed Open Access

  51. Moreno-Moral A, Mancini M, D'Amati G, Camici P, Petretto E. (2013): Transcriptional network analysis for the regulation of left ventricular hypertrophy and microvascular remodeling. J Cardiovasc Transl Res., 6(6), 931-44.
    PubMed

  52. Neckář J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštěk J, Drahota Z, Kurtz TW, Kolář F, Pravenec M (2012): CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiological Genomics, 44(2), 173-182.
    PubMed Open Access

  53. Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E (2010): Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nature Methods, 7(11), 913-5.
    PubMed

  54. Pontoizeau C, Fearnside J, Navratil V, Domange C, Cazier JB, Fernandez-Santamaria C, Kaisaki PJ, Emsley L, Toulhoat P, Bihoreau MT, Nicholson JK, Gauguier D, Dumas ME (2011): Broad-range natural metabotype variation drives physiological plasticity in control healthy inbred rat strains. J Proteome Res, 10(4), 1675-89.
    PubMed

  55. Popova E, Bader M, Krivokharchenko A (2011): Effect of culture conditions on viability of mouse and rat embryos developed in vitro. Genes, 2, 332-44.
    PubMed Open Access

  56. Popova E, Bader M, Krivokharchenko A (2011): Effects of electric field on early preimplantation development in vitro in mice and rats. Human Reproduction, 26, 662-70.
    PubMed Open Access

  57. Poulsen JW, Madsen CT, Young C, Poulsen FM, Nielsen ML (2013): Using guanidine-hydrochloride for fast and efficient protein digestion and single-step affinity-purification mass spectrometry. J Proteome Res, 12(2), 1020-30.
    PubMed

  58. Pravenec M, Kajiya T, Zídek V, Landa V, Mlejnek P, Simáková M, Silhavý J, Malínská H, Oliyarnyk O, Kazdová L, Fan J, Wang J, Kurtz TW (2011): Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome. Hypertension, 57(1), 731-37.
    PubMed Open Access

  59. Pravenec M, Kozich V, Krijt J, Sokolová J, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Oliyarnyk O, Kazdová L, Kurtz TW (2013): Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats. Am J Hypertens., 26(1), 135-40.
    PubMed Open Access

  60. Rintisch C, Heinig M, Bauerfeind A, Schafer S, Mieth C, Patone G, Hummel O, Chen W, Cook S, Cuppen E, Colomé-Tatché M, Johannes F, Jansen RC, Neil H, Werner M, Pravenec M, Vingron M, Hubner N. (2014): Natural variation of histone modification and its impact on gene expression in the rat genome. Genome Res, 24(6), 942-53.
    PubMed Open Access

  61. Rotival M, Ko JH, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR, Petretto E, Behmoaras J. (2015): Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation. Mol Cell Proteomics, 14(3), 484-98.
    PubMed Open Access

  62. Rotival M, Petretto E. (2014): Leveraging gene co-expression networks to pinpoint the regulation of complex traits and disease, with a focus on cardiovascular traits. Brief Funct Genomics, 13(1),66-78.
    PubMed

  63. Sampson AK, Mohammed D, Beattie W, Graham D, Kenyon CJ, Al-Dujaili EA, Guryev V, Mcbride MW, Dominiczak AF. (2014): Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. J Hypertens., 32(10), 2013-21.
    PubMed

  64. Schafer S, Adami E, Heinig M, Rodrigues KE, Kreuchwig F, Silhavy J, van Heesch S, Simaite D, Rajewsky N, Cuppen E, Pravenec M, Vingron M, Cook SA, Hubner N. (2015): Translational regulation shapes the molecular landscape of complex disease phenotypes. Nat Commun., 6, 7200.
    PubMed Open Access

  65. Schiavone S, Jaquet V, Sorce S, Dubois-Dauphin M, Hultqvist M, Bäckdahl L, Holmdahl R, Colaianna M, Cuomo V, Trabace L, Krause KH (2012): NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology. Transl Psychiatry, 2(5): e111
    PubMed Open Access

  66. Serikawa T, Mashimo T, Kuramoro T, Voigt B, Ohno Y, Sasa M. (2015): Advances on genetic rat models of epilepsy. Exp Anim., 64(1), 1-7.
    PubMed Open Access

  67. Šilhavý J, Zídek V, Landa V, Šimáková M, Mlejnek P, Škop V, Oliyarnyk O, Kazdová L, Mancini M, Saar K, Schulz H, Hübner N, Kurtz TW, Pravenec M. (2014): Rosuvastatin can block pro-inflammatory actions of transgenic human C-reactive protein without reducing its circulating levels. Cardiovasc Ther., 32(2), 59-65.
    PubMed Open Access

  68. Simonis M, Atanur SS, Linsen SE, Guryev V, Ruzius FP, Game L, Lansu N, de Bruijn E, van Heesch S, Jones SJ, Pravenec M, Aitman TJ, Cuppen E (2012): Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel. Genome Biology, 13(4):r31.
    PubMed Open Access

  69. Srivastava PK, Hull RP, Behmoaras J, Petretto E, Aitman TJ. (2013): JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis. BMC Syst Biol., 7, 93.
    PubMed Open Access

  70. Sylvestersen KB, Young C, Nielsen ML (2013): Advances in characterizing ubiquitylation sites by mass spectrometry. Curr Opin Chem Biol., 17(1), 49-8.
    PubMed

  71. Thessen Hedreul M, Möller S, Stridh P, Gupta Y, Gillett A, Daniel Beyeen A, Ockinger J, Flytzani S, Diez M, Olsson T, Jagodic M. (2013): Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Hum Mol Genet., 22(24), 4952-66.
    PubMed Open Access

  72. Trelles O, Prins P, Snir M, Jansen RC. (2011): Big data, but are we ready? Nat Rev Genet., 12(3), 224
    PubMed

  73. Tuncel J, Haag S, Carlsén S, Yau AC, Lu S, Burkhardt H, Holmdahl R. (2012): Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats. Arthritis Rheum, 64(8), 2537-47.
    PubMed Open Access

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jaune EURATRANS is co-funded by the European Community‘s Seventh Framework Programme (FP7/2007-2013) under grant agreement N° HEALTH-F4-2010-241504. FP7-coo-RGB
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