European large-scale functional genomics in the rat for translational research

EURATRANS: European large-scale functional genomics in the rat for translational research

European and international research project co-funded by the Seventh European Framework Programme. For enquiries, please use the contact form.

Short description

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.

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Science Magazine Breakthrough of the Year: Knockout rats are runner up!

Science Vol. 330. No 6011, p. 1605, NEWS FOCUS

Knockout rats are among the runners up of Science Magazine's Breakthrough of the Year selection. This acknowledges the recent development in zink finger nuclease, knockout and transposon technologies which could mean that "knockout and genetically modified rats may soon displace their smaller cousins in lab cages around the world".

Last Updated on Monday, 20 December 2010 10:47.


Science Magazine News: One-Two Punch Elevates Rats to the Knockout Ranks

Science Vol. 329. No 5994, p. 892 NEWS OF THE WEEK

Science Magazine NEWS OF THE WEEK on the latest developments in knockout rat technologies. Dennis Normile interviewed Tim Aitman (Imperial College London) and refers to Aron Geurths' work with Zink Finger Nuclease technolgy (Medical College of Wisconsin, Milwaukee) and Zsuzsanna Izsvaks' work with transposons (Max Delbrück Center for Molecular Medicine, Berlin), all of them Principal Investigators in the EURATRANS consortium.

Last Updated on Tuesday, 21 September 2010 16:10.


Nature Methods Editorial: Rats!

Nature Methods, Vol. 7, No. 6, June 2010, p 413: Editorial

The editorial deals with new genetic technologies in the rat and refers to the use of transposon mediated
mutagenesis to knock out genes in rat spermatogonial stem cells, published by EURATRANS participant Z. Izsvak et al. in the same issue:

Nature Methods 7, 443 - 445 (2010)
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Zsuzsanna Izsvák, Janine Fröhlich, Ivana Grabundzija, James R Shirley, Heather M Powell, Karen M Chapman, Zoltán Ivics & F Kent Hamra

International Rat Workshop 2010 in Kyoto, Japan

XVIIIth International Workshop on Genetic Systems in the Rat, 30 November - 3 December 2010, Kyoto University Campus, Japan.

Abstract Submission: September 6, 2010   extended to September 20th 2010 !
Early Registration: September 6, 2010   extended to September 20th 2010 !

Last Updated on Wednesday, 08 September 2010 09:48.


Nature Medicine News: The knockout rat pack

Nature Medicine 16, 254 - 257 (March 2010): News

Elie Dolgin, assistant news editor for Nature Medicine in New York, reports on developments in the field of targeted alterations of the rat genome, including the Zinc Finger Nuclease (ZNF) technology, homologous recombination in ES cells, transposon technology and ENU mutant technology, featuring EURATRANS participants Aron Geurts and Howard Jacob of the Medical College of Wisconsin (MCW), Milwaukee, Austin Smith of the University of Cambridge, Zsuzsanna Izsvak of the Max Delbrück Center for Molecular Medicine (MDC) in Berlin and Edwin Cuppen of the Hubrecht Institute in Utrecht, respectively.

Last Updated on Monday, 14 June 2010 11:14.


Disease Models Mechanisms Editorial: Rats!

Disease Models & Mechanisms 2, 206-210 (2009) Editorial

Philip M. Iannaccone (Developmental Biology Program, Children's Memorial Research Center, Northwestern University, Chicago, IL) and Howard J. Jacob (Department of Physiology, Pediatrics, and Human and Molecular Genetics Center, Medical College of Milwaukee, WI) on the rat as a model of human disease and the progress with ES cells.

Last Updated on Tuesday, 21 September 2010 15:54.



jaune EURATRANS is co-funded by the European Community‘s Seventh Framework Programme (FP7/2007-2013) under grant agreement N° HEALTH-F4-2010-241504. FP7-coo-RGB
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