Short descriptionGenetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.
Knockout rats are among the runners up of Science Magazine's Breakthrough of the Year selection. This acknowledges the recent development in zink finger nuclease, knockout and transposon technologies which could mean that "knockout and genetically modified rats may soon displace their smaller cousins in lab cages around the world".
Last Updated on Monday, 20 December 2010 10:47.
Science Magazine NEWS OF THE WEEK on the latest developments in knockout rat technologies. Dennis Normile interviewed Tim Aitman (Imperial College London) and refers to Aron Geurths' work with Zink Finger Nuclease technolgy (Medical College of Wisconsin, Milwaukee) and Zsuzsanna Izsvaks' work with transposons (Max Delbrück Center for Molecular Medicine, Berlin), all of them Principal Investigators in the EURATRANS consortium.
Last Updated on Tuesday, 21 September 2010 16:10.
The editorial deals with new genetic technologies in the rat and refers to the use of transposon mediated
mutagenesis to knock out genes in rat spermatogonial stem cells, published by EURATRANS participant Z. Izsvak et al. in the same issue:
Nature Methods 7, 443 - 445 (2010)
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.
Zsuzsanna Izsvák, Janine Fröhlich, Ivana Grabundzija, James R Shirley, Heather M Powell, Karen M Chapman, Zoltán Ivics & F Kent Hamra
Abstract Submission: September 6, 2010 extended to September 20th 2010 !
Early Registration: September 6, 2010 extended to September 20th 2010 !
Last Updated on Wednesday, 08 September 2010 09:48.
Elie Dolgin, assistant news editor for Nature Medicine in New York, reports on developments in the field of targeted alterations of the rat genome, including the Zinc Finger Nuclease (ZNF) technology, homologous recombination in ES cells, transposon technology and ENU mutant technology, featuring EURATRANS participants Aron Geurts and Howard Jacob of the Medical College of Wisconsin (MCW), Milwaukee, Austin Smith of the University of Cambridge, Zsuzsanna Izsvak of the Max Delbrück Center for Molecular Medicine (MDC) in Berlin and Edwin Cuppen of the Hubrecht Institute in Utrecht, respectively.
Last Updated on Monday, 14 June 2010 11:14.
Philip M. Iannaccone (Developmental Biology Program, Children's Memorial Research Center, Northwestern University, Chicago, IL) and Howard J. Jacob (Department of Physiology, Pediatrics, and Human and Molecular Genetics Center, Medical College of Milwaukee, WI) on the rat as a model of human disease and the progress with ES cells.
Last Updated on Tuesday, 21 September 2010 15:54.